I've had PEAR act up on 3 different Natty installs, generally it's shirtiness manifests itself when you go

$ sudo pear upgrade-all
> PHP Fatal error:  Call to undefined method PEAR::raiseErro() in /usr/share/php/PEAR/REST.php on line 165
PHP Stack trace:
...

You can fix this nuisance:

$ sudo mkdir -p /tmp/pear/cache
$ sudo pear upgrade-all

Hope this helps save someone some time!